MY RESEARCH BLOG

June 11, 2018

Confirmation of high-throughput screening data and novel mechanistic insights into VDR-xenobiotic interactions by orthogonal assays

Authored By:

Debabrata Mahapatra, Jill A Franzosa, Kyle Roell, Melaine Agnes Kuenemann, Keith A Houck, David M Reif, Denis Fourches, Seth W...

June 6, 2018

Predicting Adverse Drug Effects from Literature- and Database-Mined Assertions

Authored By:

La MK, Sedykh A, Fourches D, Muratov E, Tropsha A.

DOI: 

10.1007/s40264-018-0688-5

Abstract:

Introduction:

Given that adverse drug effects (ADEs) have led to post-market patient harm a...

May 29, 2018

Identifying individual risk rare variants using protein structure-guided local tests (POINT).

Authored By:

Rachel Marceau West, Wenbin Lu, Daniel M. Rotroff, Melaine Kuenemann, Sheng-Mao Chang, Michael J. Wagner, John B. Buse, Alison Motsinger-Reif, Denis Fourches, Jung-...

May 22, 2018

Exploring drug space with ChemMaps.com

Authored By:

Borrel A, Kleinstreuer N, Fourches D

Abstract:

Motivation:

Easily navigating chemical space has become more important due to the increasing size and diversity of publicly-accessible databases such as DrugBank, ChEMBL or To...

March 8, 2018

In silico Predicted Glucose‐1‐phosphate Uridylyltransferase (GalU) Inhibitors Block a Key Pathway Required for ListeriaVirulence

Authored By: 

Melaine A. Kuenemann Patricia A. Spears Paul E. Orndorff Denis Fourches

Abstract:

Peptidoglycan walls of gram positive bacter...

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