June 11, 2018
Confirmation of high-throughput screening data and novel mechanistic insights into VDR-xenobiotic interactions by orthogonal assays
Debabrata Mahapatra, Jill A Franzosa, Kyle Roell, Melaine Agnes Kuenemann, Keith A Houck, David M Reif, Denis Fourches, Seth W...
June 6, 2018
Predicting Adverse Drug Effects from Literature- and Database-Mined Assertions
La MK, Sedykh A, Fourches D, Muratov E, Tropsha A.
Given that adverse drug effects (ADEs) have led to post-market patient harm a...
May 29, 2018
Identifying individual risk rare variants using protein structure-guided local tests (POINT).
Rachel Marceau West, Wenbin Lu, Daniel M. Rotroff, Melaine Kuenemann, Sheng-Mao Chang, Michael J. Wagner, John B. Buse, Alison Motsinger-Reif, Denis Fourches, Jung-...
May 22, 2018
Exploring drug space with ChemMaps.com
Borrel A, Kleinstreuer N, Fourches D
Easily navigating chemical space has become more important due to the increasing size and diversity of publicly-accessible databases such as DrugBank, ChEMBL or To...
March 8, 2018
In silico Predicted Glucose‐1‐phosphate Uridylyltransferase (GalU) Inhibitors Block a Key Pathway Required for ListeriaVirulence
Melaine A. Kuenemann Patricia A. Spears Paul E. Orndorff Denis Fourches
Peptidoglycan walls of gram positive bacter...
Journal Club (2)
New Members (3)